The Expression Change of Mmp-8 and Collagen Type-2 Intracell in Lung Tissue Due to Electronic Smoke Exposure

The number of electronic smokers has increased annually. Exposure to an cigarette will increase free radicals in the body and result oxidative stress causing lung tissue damage. severity degree damage caused by smoke exposure depends on duration exposure, affect Matrix Metalloproteinase-8 collagen type-2 cells. study aims understand change type-2in due exposure. This applied experimental method with a post control group design. male Wistar rats were used as animal models this research assess cell through expression using immunohistochemical staining. cigarettes was given each difference amount time duration. indicated significant (ANOVA, p=0.000). Meanwhile showed decrease because Besides, MMP-8 manifested relationship existence strong impact (r=0.948, negative electric causes decreased tissue.